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Researchers say a vaginal gel containing an AIDS drug cut in half a woman's chances of getting HIV from an infected partner.
The results need to be confirmed, and scientists disagree about whether this amount of protection is enough to justify using the gel now. But it is the first hope of protection for women if their partners refuse to use condoms.
Results of the South African study are being presented at the International AIDS Conference in Vienna and were published online Monday by the journal Science.
"It's the first time we've ever seen any microbicide give a positive result that you could say was statistically significant," said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases.
The gel, spiked with the AIDS drug tenofovir, cut the risk of HIV infection by 50 percent after one year of use and 39 percent after 2 1/2 years, compared to a gel that contained no medicine.
In the study, women used the gel only 60 percent of the time; those who used it more often had higher rates of protection, and researchers said this is the key to improving effectiveness, not changing the gel. The gel also cut in half the chances of getting HSV-2, the herpes virus that causes genital warts.
Even partial protection is a huge victory that could be a boon not just in poor countries but for couples anywhere when one partner has the AIDS virus and the other does not, said Dr. Salim Abdool Karim, the South African researcher who led the study.
